The main objective of WP6: Risk Assessment is to characterise and quantify impacts of persistent and mobile substances on human health and the environment.
This will be achieved by developing the following:
▼ Better models for external human exposure to persistent and mobile substances.
▼ Models translating in vitro effect concentrations to human relevant internal doses to external exposure scenarios.
▼ Toolbox for persistent and mobile hazard assessment.
▼ Risk matrix for screening and prioritization of persistent and mobile substances.
▼ Identification of bioactive persistent and mobile contaminants of emerging concern.
There is currently limited understanding related to the risks associated with long term chronic exposure to persistent and mobile substances in drinking water or the environment, and how to foresee these hazards or risks. Methods are needed to improve and expand the applicability domain of existing environmental fate and exposure models. For mobile substances, robust hazard assessment frameworks are also urgently needed, incorporating innovative human-relevant methods to facilitate a refined understanding of the persistent and mobile substance’s mechanisms of toxicity.
WP6 is led by Dr. Timo Hamers from Vrije Universiteit Amsterdam who will focus on of in silico, in vitro and in vivo toolboxes for persistent and mobile substance hazard assessment. In addition, partner TGER will lead external exposure assessment work and Fraunhofer ITEM will lead the PBPK modelling and the development of a risk matrix for screening and prioritization. DVGW will also support WP6 via analytical tools developed.